One of a number of different cells that play a part in the body's defences and give immunity against disease. Some (neutrophils and macrophages) engulf invading micro-organisms, others kill infected cells, while lymphocytes produce more specific immune responses. White blood cells are colourless, with clear or granulated cytoplasm, and are capable of independent amoeboid movement. They occur in the blood, lymph, and elsewhere in the body's tissues. Unlike mature red blood cells they contain a nucleus.
Human blood contains about 11,000 leucocytes to the cubic millimetre – about one to every 500 red blood cells. White blood cell numbers may be reduced (leucopenia) by starvation, pernicious anaemia, and certain infections, such as typhoid and malaria. An increase in their numbers (leucocytosis) is a reaction to normal events such as digestion, exertion, and pregnancy, and to abnormal ones such as loss of blood, cancer, and most infections.
Some white cells can produce antibodies. Antibodies are specific proteins that can attach to chemicals that do not belong to the body, such as toxins or chemicals on disease-causing bacteria. Chemicals that do not belong to the body are said to be ‘foreign’. If these chemicals cause the body to produce antibodies, they are called antigens. Once these foreign chemicals have contacted the blood, some white blood cells can retain the memory of the particular antibody that is needed for defence. The next time the antibody is needed it is produced quickly and in large amounts to prevent the body being harmed – the body shows immunity to the disease. This is also the basis of immunization by a vaccine.
Constituents of blood
How Blood Helps to Prevent Disease
Immunity: T and B cells and monoclonal antibodies
Defence mechanisms, immunization and medicines
Using Monoclonal Antibodies
white blood cell
white blood cells fight infection
A colourless blood cell, up to 0.02 mm in diameter, of which there are normally 4000-11 000 per cubic millimetre of blood. There are...
any of the blood cells of the immune system that are colorless, lack hemoglobin, contain a nucleus, and include the lymphocytes, monocytes, neutroph
This chapter includes text excerpted from “CTLA4 Deficiency,” National Institute of Allergy and Infectious Diseases (NIAID), July 25, 2016.CTLA4 def