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Definition: tardive dyskinesia from The Macquarie Dictionary

a disorder of movement characterised by abnormal uncontrollable movements of the mouth, lips, tongue, and jaws; associated with the long-term use of antipsychotic medication.

Etymology: a rare variant tardive of French tardif late + dyskinesia

Summary Article: Tardive Dyskinesia
From Encyclopedia of Psychopharmacology

Tardive dyskinesia (TD) is a chronic neuromotor side effect of dopamine-blocking medications, characterized by abnormal involuntary movements of voluntary musculature that are generally slow and that can be irreversible. It can include abnormal rotatory or sinuous movements of the mouth, lips, neck, trunk, hands, arms, and legs. It is identified as a side effect of long-term antipsychotic use; risk factors have been identified (e.g., age, duration of exposure), but there is no specific means of precisely predicting who will develop TD. With the ► first-generation antipsychotics, prevalence rates in chronically treated patients approximated to 25%. Evidence for the newer, ► “atypical” antipsychotics indicates that none of these agents are without risk of TD, although prevalence rates appear notably lower. The precise pathophysiologic mechanisms underlying TD have not been elucidated, although high and sustained levels of dopamine D2 occupancy have been implicated. Many putative pharmacologic treatments have been investigated, although only a few (e.g., ► tetrabenazine in Canada) have gained an indication for treatment of TD. TD has proven inconsistent in its response to all treatments, variable over the course of the illness, and is frequently irreversible. Other tardive movements (e.g., tardive dystonia) are also linked to chronic antipsychotic exposure.

  • Antipsychotics
  • First-Generation Antipsychotics
  • Schizophrenia
  • Second-Generation Antipsychotics
© Springer Science+ Business Media B.V. 2010

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