Sauter vers contenu principal Sauter vers case de recherche

Definition: Cysteine from Black's Medical Dictionary, 43rd Edition

An AMINO ACID that is an essential constituent of many of the body's ENZYMES.

Summary Article: cysteine
From The Columbia Encyclopedia

(sĭs'tēn), organic compound, one of the 20 amino acids commonly found in animal proteins. Only the l-stereoisomer participates in the biosynthesis of mammalian protein. It is particularly abundant in the proteins of hair, hooves, and the keratin of the skin. Cysteine's importance is related to the presence of a sulfur-containing thiol group in its side chain. This group participates in the catalytic reactions of certain enzymes, such as that of papain, the enzyme from papaya latex used to make commercial meat tenderizers. The thiol group of one cysteine residue is capable of combining with the thiol group of another to form a disulfide bridge, either linking two peptide chains together, as in the case of insulin, or causing a single peptide chain to fold back on itself, making a loop. This latter effect on the secondary structure of proteins is evidently of great importance in maintaining the proper configuration of both structural proteins and enzymes. Two cysteine molecules linked together by a disulfide linkage make up the amino acid cystine, often occurring as a separate entry in lists of common amino acids. A major complication of cystinuria, an inherited metabolic disease, one of whose symptoms is a twentyfold to thirtyfold increase in urinary excretion of cystine, is the precipitation of this relatively insoluble amino acid in the kidney, impairing its function. A similar sort of renal failure often accompanies cystinosis, another inherited disease. Cystine was isolated from a urinary calculus in 1810 and from horn tissue in 1899. The reduction of cystine to cysteine was reported in 1884, and the structures of the two amino acids were proved by chemical synthesis in 1903–4. Neither cysteine nor cystine is essential to the diet of man; cystine and cysteine are interconvertible, and cysteine is made in the body from serine and methionine.

The Columbia Encyclopedia, © Columbia University Press 2018

Articles reliés dans Credo

Full text Article Cysteine
The Encyclopedia of Farm Animal Nutrition

An amino acid (HS·CH 2 ·CH·NH 2 ·COOH, molecular weight 121.2) found in protein. It is synthesized from methionine (which provides the sulphur)...

Full text Article cysteine
Britannica Concise Encyclopedia

Sulfur-containing nonessential amino acid. In peptides and proteins, the sulfur atoms of two cysteine molecules are bonded to each other to make cy

Full text Article cystine
Merriam-Webster's Medical Dictionary

an amino acid C6H12N2O4S2 that is a dimer of cysteine, is widespread in proteins (as keratins), and is a major metabolic sulfur source

Voir plus dans Credo