Skip to main content Skip to Search Box

Definition: antibody from Philip's Encyclopedia

Protein synthesized in the blood in response to the entry of "foreign" substances or organisms into the body. Each episode of bacterial or viral infection prompts the production of a specific antibody to fight the disease in question. After the infection has cleared, the antibody remains in the blood to fight off any future invasion.


Summary Article: antibody from The Hutchinson Unabridged Encyclopedia with Atlas and Weather Guide

Protein molecule produced in the blood by lymphocytes in response to the presence of foreign or invading substances (antigens); such substances include the proteins carried on the surface of infecting micro-organisms. Antibody production is only one aspect of immunity in vertebrates.

Each antibody acts against only one kind of antigen, and combines with it to form a ‘complex’. This action may render antigens harmless, or it may destroy micro-organisms by setting off chemical changes that cause them to self-destruct.

In other cases, the formation of a complex will cause antigens to form clumps that can then be detected and engulfed by white blood cells, such as macrophages and phagocytes.

Each bacterial or viral infection will bring about the manufacture of a specific antibody, which will then fight the disease. Many diseases can only be contracted once because antibodies remain in the blood after the infection has passed, preventing any further invasion. Vaccination boosts a person's resistance by causing the production of antibodies specific to particular infections.

Large quantities of specific antibodies can now be obtained by the monoclonal technique (see monoclonal antibody).

Antibodies were discovered in 1890 by the German physician Emil von Behring and the Japanese bacteriologist Shibasaburo Kitasato.

In 1989 a Cambridge University team developed genetically engineered bacteria to make a small part of an antibody (single domain antibodies) which bind to invaders such as toxins, bacteria, and viruses. Since they are smaller, they penetrate tissues more easily, and are potentially more effective in clearing organs of toxins. They can be produced more quickly, using fewer laboratory mice, and unlike conventional antibodies, they also disable viruses. In addition, single domain antibodies can be used to highlight other molecules, such as hormones in pregnancy testing.

essays

Forensic Science: Recent Advances

Defence mechanisms, immunization and medicines

weblinks

Antibody Resource Page

© RM, 2016. All rights reserved.

Related Credo Articles

Full text Article au•to•ag•glu•ti•nin
Stedman's Medical Dictionary

(aw′tō-ă-glū′ti-nin). An agglutinating autoantibody. anti-Pr cold autoagglutinin a cold autoagglutinin specific for the Pr...

Full text Article seroconvert
Collins English Dictionary

vb 1 (intr) (of an individual) to produce antibodies specific to, and in response to the presence in the blood of, a particular antigen, such as a

Full text Article antibody
The Macmillan Encyclopedia

A protein produced by certain white blood cells (lymphocytes) that reacts specifically with and neutralizes a foreign protein (e.g. a...

See more from Credo